|
|Section2= |Section3= }} Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography.〔(Definition of indocyanine green ), National Cancer Institute〕 It has a peak spectral absorption at about 800 nm.〔(Optical Absorption of Indocyanine Green (ICG) ), Oregon Medical Laser Center〕 These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than fluorescein angiography.〔(Ophthalmic Diagnostic Photography; Indocyanine Green (ICG) Angiography ) University of Iowa Health Care〕 ICG binds tightly to plasma proteins and becomes confined to the vascular system.〔 ICG has a half-life of 150 to 180 seconds and is removed from circulation exclusively by the liver to bile juice.〔 ICG is a fluorescent dye which is used in medicine as an indicator substance (e.g. for photometric hepatic function diagnostics and fluorescence angiography) in cardiac, circulatory, hepatic and ophthalmic conditions. It is administered intravenously and, depending on liver performance, is eliminated from the body with a half life of approx. 3–4 minutes. ICG sodium salt is normally available in powder form and can be dissolved in various solvents; 5% (<5% depending on batch) sodium iodide is usually added to ensure better solubility.〔Augustin, A.J., Krieglstein, G.K.,: ''Augenheilkunde'', 2001, Springer-Verlag, ISBN 3-540-65947-1〕 The sterile lyophilisate of a water-ICG solution is approved many European countries and the United States under the names ICG-Pulsion and IC-Green as a diagnostic for intravenous use. == History == ICG was developed in the Second World War as a dye in photography and tested in 1957 at the Mayo Clinic for use in human medicine. After being granted FDA approval in 1959, ICG was initially used primarily in hepatic function diagnostics and later in cardiology. In 1964, S. Schilling was able to determine renal blood flow using ICG. From 1969, ICG was also used in the research and diagnosis of subretinal processes in the eye (in the choroid). In the years since 1980, the development of new types of cameras and better film material or new photometric measuring devices has cleared away many technical difficulties. In the mean time, the use of ICG in medicine (and especially in fluorescent angiography in ophthalmology) has become established as standard. A distinction is therefore also made, when describing fluorescent angiography, between NA fluorescent angiography and ICGA / ICG fluorescent angiography. Around 3,000 scientific papers on ICG have now been published worldwide. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Indocyanine green」の詳細全文を読む スポンサード リンク
|